289505-18-6

Basic information

• Product Name: (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol
• Synonyms: (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol
• CAS NO: 289505-18-6
• Molecular Weight: 533.455
• Mol File: 289505-18-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol(289505-18-6)
• EPA Substance Registry System: (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol(289505-18-6)

Safety Data

• Hazardous Substances Data: 289505-18-6(Hazardous Substances Data)

Upstream product

• 289505-15-3 Acetic acid (1S,2S,3R,4S,6R)-4,6-diazido-3-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-2-((2S,3R,4R,5R)-3,4-diacetoxy-5-acetoxymethyl-tetrahydro-furan-2-yloxy)-cyclohexyl ester 
• 918800-32-5 C₄₆H₄₇N₉O₁₈ 
• 534-47-4 Paromamine 
• 289505-10-8 (2R,3S,4R,5R,6S)-5-azido-6-(((1R,2R,3S,4R,6S)-4, 6-diazido-2,3-dihydroxycyclohexyl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol 
• 289505-11-9 Acetic acid (1S,2S,3R,4S,6R)-4,6-diazido-3-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyl ester 
• 7542-37-2 paromomycin 
• 289505-12-0 Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-cyclohexyl ester 

Downstream Products

• 55781-25-4 6'-hydroxyl-ribostamycin 

Relevant articles and documents

Novel aminoglycosides and uses thereof in the treatment of genetic disorders

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Efficient synthesis of neomycin B related aminoglycosides

Aminoglycosides 6'-hydroxyl-ribostamycin and 5-(α-neobiosamine)-2- deoxystreptamine were chemically synthesized. These compounds will be used as standards to compare RNA binding affinity and specificity with neomycin B. (C) 2000 Elsevier Science Ltd.