55781-25-4

Basic information

• Product Name: (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(beta-D-ribofuranosyloxy)cyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
• Synonyms: alpha-D-glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(beta-D-ribofuranosyloxy)cyclohexyl 2-amino-2-deoxy-
• CAS NO: 55781-25-4
• Molecular Formula: C₁₇H₃₃N₃O₁₁
• Molecular Weight: 455.4574
• Mol File: 55781-25-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 784.9°C at 760 mmHg
• Flash Point: 428.5°C
• Density: 1.64g/cm³
• Vapor Pressure: 1.82E-28mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(beta-D-ribofuranosyloxy)cyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(beta-D-ribofuranosyloxy)cyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside(55781-25-4)
• EPA Substance Registry System: (1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-(beta-D-ribofuranosyloxy)cyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside(55781-25-4)

Safety Data

• Hazardous Substances Data: 55781-25-4(Hazardous Substances Data)

Upstream product

• 289505-15-3 Acetic acid (1S,2S,3R,4S,6R)-4,6-diazido-3-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-2-((2S,3R,4R,5R)-3,4-diacetoxy-5-acetoxymethyl-tetrahydro-furan-2-yloxy)-cyclohexyl ester 
• 289505-12-0 Acetic acid (1S,2S,3R,5S,6R)-2-acetoxy-3,5-diazido-6-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-cyclohexyl ester 
• 7542-37-2 paromomycin 
• 289505-11-9 Acetic acid (1S,2S,3R,4S,6R)-4,6-diazido-3-((2S,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-azido-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyl ester 
• 289505-10-8 (2R,3S,4R,5R,6S)-5-azido-6-(((1R,2R,3S,4R,6S)-4, 6-diazido-2,3-dihydroxycyclohexyl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol 
• 534-47-4 Paromamine 
• 289505-18-6 (2R,3S,4R,5R,6S)-5-Azido-6-[(1R,2R,3S,4R,6S)-4,6-diazido-2-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-hydroxy-cyclohexyloxy]-2-hydroxymethyl-tetrahydro-pyran-3,4-diol 
• 918800-32-5 C₄₆H₄₇N₉O₁₈ 

Downstream Products

• 1141768-90-2 C₂₆H₄₇N₅O₁₆ 

Relevant articles and documents

Novel aminoglycosides and uses thereof in the treatment of genetic disorders

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations

A series of new derivatives of the clinically used aminoglycoside antibiotic paromomycin were designed, synthesized, and their ability to read-through premature stop codon mutations was examined in both in vitro translation system and ex vivo mammalian cultured cells. One of these structures, a pseudo-trisaccharide derivative, showed notably higher stop codon read-through activity in cultured cells compared to those of paromomycin and gentamicin.