289619-01-8Relevant academic research and scientific papers
Ring closing metathesis for the formation of medium ring ethers: The total synthesis of (-)-isolaurallene
Crimmins, Michael T,Emmitte, Kyle A,Choy, Allison L
, p. 1817 - 1834 (2007/10/03)
The total synthesis of the marine metabolite (-)-isolaurallene is described. Two approaches to the core nine-membered ether are presented both of which are based on a ring closing metathesis to close the cyclic ether.
An efficient strategy for the synthesis of α,α'-cis and trans- disubstituted medium ring ethers
Crimmins, Michael T.,Emmitte, Kyle A.
, p. 899 - 903 (2007/10/03)
An asymmetric alkylation-ring-closing metathesis strategy was developed for the construction of α,α'-disubstituted medium ring ethers. The approach features an asymmetric alkylation of highly functionalized α-alkoxy acyl oxazolidinones followed by ring closure effected by Grubbs' ruthenium catalyst. The relationship between diene conformation and the rate of ring- closure was examined.
