2897-00-9

Usage

Uses

2-Cyclopropylmethylamino-5-chlorobenzophenone is a benzodiazepine derivative.

InChI:InChI=1/C17H16ClNO/c18-14-8-9-16(19-11-12-6-7-12)15(10-14)17(20)13-4-2-1-3-5-13/h1-5,8-10,12,19H,6-7,11H2

Upstream product

• 2955-38-6 prazepam 
• 201230-82-2 carbon monoxide 
• 67-56-1 methanol 
• 40507-46-8 5-chloro-2-cyclopropylmethylaminobenzophenone imine 
• 76-02-8 trifluoroacetyl chloride 
• 18818-61-6 3-Hydroxyprazepam 

Relevant academic research and scientific papers

Cyclometallated derivatives of palladium(II) with 1,4-benzodiazepin-2-ones. Crystal structure of (L-H)Pd(PPh3)ClCHCl3 (L = Prazepam: 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one). Synthesis of isoindolobenzodiazepine derivatives by ...

The dimeric cyclometallated derivatives of palladium(II) 2, 3 (L = 1, Diazepam: 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) and 4 (L = 2, Prazepam: 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one) react with triphenylphosphine to give the complexes (L-H)Pd(PPh3)Cl, 5 (L = Diazepam) and 6 (L = Prazepam).The crystal structure of 6 was determined by X-ray crystallography.The palladium atom is in a square planar arrangement.The deprotonated ligand is bound to the metal through the 4-nitrogen and the ortho-carbon atom of the 5-phenyl substituent.The phosphorous and the chlorine atoms are trans to the nitrogen and the carbon atoms, respectively: Pd-N = 2.085(2), Pd-P = 2.263(1), Pd-Cl = 2.377(1), Pd-C = 2.009(3) Angstroem.The reaction of the dimeric derivatives 2 with carbon monoxide was investigated.Under mild conditions (1 atm of CO, room temperature) the unstable (L-H)Pd(CO)Cl derivatives, 7 (L = Diazepam) and 8 (L = Prazepam) are formed, but at high pressure and temperature (60-100 atm of CO, 45-50 deg C), extrusion of palladium occurs and tetracyclic derivatives having an isoindolo ring condensed on the 1,4-benzodiazepin-2-one system, 9-12, are obtained.

Screening, detection and biotransformation of lormetazepam, a new hypnotic agent from the 1,4-benzodiazepine series

The paper describes a screening procedure for 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiaze pin-2-one (lormetazepam, Noctamid) and other important analytical data (TLC, GLC, UV-, IR- and mass spectra) of this new benzodiazepine derivative. Screening results after a single p.o. dose of 1 mg lormetazepam (Noctamid-1) are also reported.