2897-83-8 Usage
Originator
Alonimide ,ZYF Pharm
Chemical
Uses
Sedativehypnotic.
Manufacturing Process
To a stirred mixture of 58.6 g (0.5 M) of phenyl-acetonitrile and 150 g (1.5 M)
of ethyl acrylate was carefully added sodium methoxide in small increments
(about 0.1 g). The exothermic reaction was controlled by ice bath cooling to
keep the reaction mixture at 50°C. When further additions of sodium
methoxide were no longer exothermic, the reaction mixture was stirred for
one half hour more and the excess ethyl acrylate removed under reduced
pressure on a steam bath. The resulting oil was added to 1.500 g of
polyphosphoric acid and stirred on a steam bath for three hours. After cooling
to about 50°C, 0.5 liter of chloroform was added followed by additions of
crushed ice until the aqueous phase was free flowing. The chloroform layer
was separated and combined with three 150 ml chloroform extracts of the
aqueous layer. The organic phase was then dried over anhydrous magnesium
sulfate, filtered and concentrated to a semi-solid residue.
Recrystallization from acetone gave 2,3-dihydrospiro[naphthalene-1(4H),3'-
piperidine]-2',4,6'-trione, melting point 197°-199°C.
Therapeutic Function
Sedative, Hypnotic
Check Digit Verification of cas no
The CAS Registry Mumber 2897-83-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,9 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2897-83:
(6*2)+(5*8)+(4*9)+(3*7)+(2*8)+(1*3)=128
128 % 10 = 8
So 2897-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H13NO3/c16-11-5-7-14(8-6-12(17)15-13(14)18)10-4-2-1-3-9(10)11/h1-4H,5-8H2,(H,15,17,18)
2897-83-8Relevant academic research and scientific papers
Methods of inducing sedation using certain spiroalkanone-imides
-
, (2008/06/13)
Compounds having the general formula: SPC1 Wherein R1 and R2 represent hydrogen, halogen, lower alkyl, lower alkoxy, or nitro, and wherein R1 and R2 may be the same or different. R3 may be hydrogen or lower alkyl, and X and Y may be one or two. They have been found to be useful sedative type depressants of the central nervous system. Most of the compounds having the general formula indicated above are new but others such as 2,3-dihydrospiro[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione which has useful sedative properties have been reported in the literature.
