28973-67-3Relevant academic research and scientific papers
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
Lang, Karen Luise,Silva, Izabella Thaís,Zimmermann, Lara Almida,MacHado, Vanessa Rocha,Teixeira, Marina Rodrigues,Lapuh, María Ivana,Galetti, Mariana Alejandra,Palermo, Jorge Alejandro,Cabrera, Gabriela Myriam,Bernardes, Lílian Sibelle Campos,Sim?es, Cláudia Maria Oliveira,Schenkel, Eloir Paulo,Caro, Miguel Soriano Balparda,Durán, Fernando Javier
experimental part, p. 3016 - 3030 (2012/06/18)
Two cucurbitacins, dihydrocucurbitacin B (1) and cucurbitacin B (2), which can be obtained in large amounts from the roots of Wilbrandia ebracteata and from the fruits of Luffa operculata, respectively, were used as starting materials for the preparation of a library of 29 semi-synthetic derivatives. The structural changes that were performed include the removal, modification or permutation of functional groups in rings A and B as well as in the side chain. All new semisynthetic compounds, as well as 1 and 2, were tested in vitro for their cytotoxic effects on non-small-cell lung cancer cells (A549 cells). Some of these compound displayed potent to moderate activity against A549 tumor cells, especially those cucurbitacin B derivatives which were modified at ring A.
