28977-50-6Relevant academic research and scientific papers
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors
Vaisburg, Arkadii,Paquin, Isabelle,Bernstein, Naomy,Frechette, Sylvie,Gaudette, Frederic,Leit, Silvana,Moradei, Oscar,Raeppel, Stephane,Zhou, Nancy,Bouchain, Giliane,Woo, Soon Hyung,Jin, Zhiyun,Gillespie, Jeff,Wang, James,Fournel, Marielle,Yan, Pu Theresa,Trachy-Bourget, Marie-Claude,Robert, Marie-France,Lu, Aihua,Yuk, Jimmy,Rahil, Jubrail,MacLeod, A. Robert,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 6729 - 6733 (2008/03/18)
A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
