39172-65-1

Basic information

• Product Name: Benzoic acid, 4-[(2,3-dihydro-1-oxo-1H-inden-2-yl)methyl]-, methyl ester
• CAS NO: 39172-65-1
• Molecular Formula: C18H16O3
• Molecular Weight: 280.323
• Mol File: 39172-65-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(2,3-dihydro-1-oxo-1H-inden-2-yl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(2,3-dihydro-1-oxo-1H-inden-2-yl)methyl]-, methyl ester(39172-65-1)
• EPA Substance Registry System: Benzoic acid, 4-[(2,3-dihydro-1-oxo-1H-inden-2-yl)methyl]-, methyl ester(39172-65-1)

Safety Data

• Hazardous Substances Data: 39172-65-1(Hazardous Substances Data)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 83-33-0 inden-1-one 
• 99-94-5 p-Toluic acid 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 61463-59-0 2-allyl benzoic acid methyl ester 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 29045-93-0 α,α-dibromo-p-toluic acid 

Downstream Products

• 28977-50-6 4-(1-Oxo-indan-2-ylmethyl)-benzoic acid 

Relevant articles and documents

Boronic Acid-Mediated Photocatalysis Enables the Intramolecular Hydroacylation of Olefins Using Carboxylic Acids

An intramolecular hydroacylation of olefins using carboxylic acids (CAs) has been developed. With the aid of a boronic acid, CAs can be used as acyl-radical precursors in catalytic photoredox reactions driven by visible light. The CAs are easily converted into their corresponding cyclic ketones without the need to use any stoichiometric activating reagents. Mechanistic studies implied that the formation of an “ate” complex from the CA and boronic acid is crucial for the generation of the acyl radical equivalent from the unreactive carboxy group.

N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors

A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC50 values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21WAF1/Cip1, and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.