2898-76-2 Usage
Uses
Used in Pharmaceutical Industry:
Benzamil Hydrochloride is used as a therapeutic agent for the treatment of certain medical conditions. Its ability to block sodium channels and inhibit ENaC makes it a potential candidate for the management of conditions related to ion channel dysfunction.
Used in Research and Development:
In the field of research, Benzamil Hydrochloride is utilized as a research tool to study the role of sodium channels and ENaC in various physiological and pathological processes. Its specificity as a blocker allows scientists to investigate the underlying mechanisms and potential therapeutic targets for a range of diseases.
Used in Drug Development:
Benzamil Hydrochloride serves as a lead compound in the development of new drugs targeting sodium channels and ENaC. Its structural similarity to Amiloride and its known effects on these channels make it a valuable starting point for designing and synthesizing novel therapeutic agents with improved efficacy and selectivity.
Used in Toxicology Studies:
Benzamil Hydrochloride is employed in toxicology research to evaluate the potential toxic effects of sodium channel blockers and ENaC inhibitors. This helps in understanding the safety profile of these compounds and their potential side effects when used as therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 2898-76-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,9 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2898-76:
(6*2)+(5*8)+(4*9)+(3*8)+(2*7)+(1*6)=132
132 % 10 = 2
So 2898-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H14ClN7O.ClH/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H
2898-76-2Relevant academic research and scientific papers
Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I
Murai, Masatoshi,Habu, Sayako,Murakami, Sonomi,Ito, Takeshi,Miyoshi, Hideto
, p. 1061 - 1066 (2015/10/05)
Amilorides, well-known inhibitors of Na+/H+ antiporters, have also shown to inhibit bacterial and mitochondrial NADH-quinone oxidoreductase (complex I). Since the membrane subunits ND2, ND4, and ND5 of bovine mitochondrial complex I
NOVEL PROCESS FOR THE PREPARATION OF ACYLGUANIDINES AND ACYLTHIOUREAS
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Page/Page column 37; 38, (2013/05/22)
The present invention relates to a novel process for the preparation of compounds of general formula (I) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.
