28991-09-5Relevant articles and documents
Lewis acid-catalyzed annulative partial dimerization of 3-aryloxyacrylates to 4-arylchroman-2-ones: Synthesis of analogues of tolterodine, RORγ inhibitors and a GPR40 agonist
Kunkalkar, Rupesh A.,Fernandes, Rodney A.
, p. 2313 - 2316 (2019)
A beguiling annulative partial dimerization of 3-aryloxyacrylates to 4-arylchroman-2-ones catalyzed by Lewis acid (BF3·OEt2) has been developed. The reaction involves two molecules of 3-aryloxyacrylate, resulting in the loss of one propiolate molecule to furnish 4-arylchroman-2-one, an important structural motif found in many natural products. This methodology has been elaborated to synthesize analogues of tolterodine, RORγ inhibitors and a GPR40 agonist.
Palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates: An approach to construct substituted benzofurans from phenols
Li, Chengliang,Zhang, Yicheng,Li, Pinhua,Wang, Lei
body text, p. 4692 - 4696 (2011/07/08)
In this paper, a novel and applicable synthesis of benzofurans from commercially available phenols and propiolate through the direct oxidative cyclization has been developed. In the presence of Pd(OAc)2/PPh 3 and CF3COsub