289911-20-2Relevant academic research and scientific papers
An intramolecular arylation route to the kinafluorenones
Qabaja, Ghassan,Jones, Graham B.
, p. 5317 - 5320 (2000)
Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of kinafluorenone 2, providing an effective alternative to Friedel-Crafts-based approaches. (C) 2000 Elsevier Science Ltd.
An efficient copper-catalytic system for performing intramolecular O-arylation reactions in aqueous media. New synthesis of xanthones
Barbero, Nekane,Sanmartin, Raul,Dominguez, Esther
supporting information; experimental part, p. 830 - 836 (2010/04/23)
A safe, efficient protocol for the copper-catalysed intramolecular O-arylation of 2-halobenzophenones on water to afford the valuable xanthone framework is reported. The recovery and the successful reutilization of the aqueous solution containing the copp
Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.
Qabaja,Jones
, p. 7187 - 7194 (2007/10/03)
Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.
