29022-36-4Relevant academic research and scientific papers
Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones
Lominac, William J.,D'Angelo, Megan L.,Smith, Mark D.,Ollison, Darius A.,Hanna Jr., James M.
supporting information; experimental part, p. 906 - 909 (2012/03/10)
3-Acylpyridine N-oxide tosylhydrazones give good overall yields of a mixture of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines when treated with an electrophilic additive and an amine base. (Z)-Hydrazones cyclize readily, while (E)-hydrazones fail
A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide- urea complex
Caron, Stéphane,Do, Nga M.,Sieser, Janice E.
, p. 2299 - 2302 (2007/10/03)
A general method for the oxidation of electron-poor pyridines to their N-oxides using UHP and TFAA in either CH2Cl2 or CH3CN was developed. The methodology proved to tolerate a number of functional groups and substitution
