39585-76-7Relevant academic research and scientific papers
Magnesiation of pyridine N-oxides via iodine or bromine-magnesium exchange: A useful tool for functionalizing pyridine N-oxides
Duan, Xin-Fang,Zi-Qian, Ma.,Zhang, Fang,Zhang, Zhan-Bin
supporting information; experimental part, p. 939 - 942 (2009/06/20)
Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl ? LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.
ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE α-HYDROXYBENZYLPYRIDINES
Takeshita, Mitsuhiro,Yoshida, Sachiko,Sato, Takumi,Akutsu, Nami
, p. 879 - 884 (2007/10/02)
Synthesis of optically active α-hydroxybenzylpyridines by asymmetric reduction of benzoylpyridines and benzoylpyridine N-oxides with baker's yeast, and enantioselective esterification of racemic α-hydroxybenzylpyridines by use of lipase PS have been described.
