2903-35-7

Upstream product

• 824-79-3 sodium 4-methylbenzenesulfinate 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 95-53-4 o-toluidine 
• 80-28-4 N-(2-methylphenyl)-p-toluenesulphonamide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 62790-50-5 4-chloro-2-methyl-6-nitrophenylamine 
• 95-69-2 4-chloro-2-methylbenzeneamine 

Relevant academic research and scientific papers

Method for synthesizing P-chloroO-toluidine

The invention discloses a method for synthesizing p-chloroo-toluidine, which comprises the following steps: synthesizing o-toluidine and a protective agent in an organic solvent to obtain an amino-protected intermediate. The amino protected intermediate is added into hydrochloric acid, an oxidant is added for chlorination reaction, and a chlorination product is obtained. The chlorinated product is removed and the amino protecting group is removed to give p-chloroo-toluidine. The method for synthesizing p-chloroo-toluidine provided by the invention is high in yield, simple to operate, less in three wastes, high in product content and good in quality, and can be suitable for industrial mass production.

NaI-Catalyzed Oxidative Amination of Aromatic Sodium Sulfinates: Synergetic Effect of Ethylene Dibromide and Air as Oxidants

A novel NaI-catalyzed oxidative amination of sodium sulfinates, employing both ethylene dibromide (EDB) and air as the oxidants, is described. EDB was first demonstrated to be a promising mild organic oxidant that in air, converted NaI into molecular iodine to promote the cross-coupling reactions of aromatic sodium sulfinates with amines to produce arylsulfonamides. Mechanistic studies indicated that a radical pathway might be involved in the reaction process.