2903-37-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 60-29-7 diethyl ether 
• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 
• 7782-50-5 chlorine 

Downstream Products

• 946161-99-5 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide 
• 1388136-04-6 N-(2-((4-methoxyphenyl)ethynyl)-4-methylphenyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Revisiting 1-chloro-1,2-benziodoxol-3-one: Efficient: ortho -chlorination of aryls under aqueous conditions

The application of 1-chloro-1,2-benziodoxol-3-one as a powerful chlorinating agent as well as oxidant for aniline derivatives is explored. The amide directing group assisted radical mediated ortho-selective chlorination proceeds in the absence of a radical initiator. Various electronically differentiated anilides and sulfonamides are tolerated under aqueous conditions.

Direct C-H substitution reaction of anilides using hypervalent iodine and their regioselective issues

The direct C-H substitution reactions of anilides using hypervalent iodine proceeded to afford azide, chloro, bromo, and fluoro derivatives, and their regioselectivity were described. In the specific reaction conditions, the unique regioisomers were obtai

One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst

Disubstituted benzo[b]furans were synthesized by ortho-selective Sonogashira coupling of dichlorophenols and terminal alkynes, followed by cyclization and Suzuki-Miyaura coupling in one pot, using a palladium-dihydroxyterphenylphosphine (Cy-DHTP) catalyst. The use of substoichiometric amounts of tetrabutylammonium chloride was effective in accelerating the Suzuki-Miyaura coupling. This protocol was also successfully applied to the one-pot synthesis of disubstituted indoles from dichloroaniline derivatives.