290307-07-2

Upstream product

• 592533-99-8 5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-pyridine-2-carboxylic acid methoxy-methyl-amide 
• 552287-61-3 (+/-)-4-{2-[3,4-bis(difluoromethoxy)phenyl]-2-[5-(2-carbomethoxy)pyridyl]ethyl}pyridine 
• 303165-22-2 (+/-)-4-{2-[3,4-bis(difluoromethoxy)phenyl]-2-[5-(2-bromo)pyridyl]ethyl}pyridine 
• 100-59-4 phenylmagnesium chloride 
• 290307-05-0 {5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-pyridin-2-yl}-phenyl-methanone 

Relevant academic research and scientific papers

Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors

The synthesis and the phosphodiesterase-4 (PDE4) inhibitory activity of 2-pyridinemethanol derivatives is described. The evaluation of the structure-activity relationship (SAR) in this series of novel PDE4 inhibitors led to the identification of compound