290307-36-7

Upstream product

• 552287-64-6 5-bromo-2-{1-methyl-1-[(2-trimethylsilylethoxy)methoxy]ethyl}pyridine 
• 290307-40-3 2-(5-bromopyridin-2-yl)propan-2-ol 
• 624-28-2 2,5-dibromopyridine 
• 290307-34-5 (+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[1-methyl-1-(2-trimethylsilylethoxy)methoxy]ethyl-pyridin-5-yl}methanol 

Downstream Products

• 1055709-55-1 3-{carbethoxy-2-(3-cyclopropyloxy-4-difluoromethoxyphenyl)-2-[2-(2-((2-trimethylsilylethoxy)methoxy)-propan-2-yl)5-pyridyl]ethyl}pyridine 
• 1026683-01-1 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-3-{6-[1-methyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-pyridin-3-yl}-2-(1-oxy-pyridin-3-yl)-propionic acid 
• 290307-35-6 (+/-)-4-{2-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]-2-[5-(2-(1-methyl-1-[(2-trimethylsilylethoxy)methoxy])ethyl)pyridyl]ethyl}pyridine 
• 552287-65-7 (+/-) 3-{2-(3-cyclopropyloxy-4-difluoromethoxyphenyl)-2-[2-(2-hydroxypropan-2-yl)5-pyridyl]ethyl}pyridine-N-oxide 

Relevant academic research and scientific papers

DI-ARYL-SUBSTITUTED-ETHANE PYRIDONE PDE4 INHIBITORS

Di-aryl substituted ethane pyridones, particularly ethane pyridones substituted with i) a phenyl, ii) a pyridyl, iii) a thiazole, iv) a pyrimidinyl, v) a pyridazinyl, vi) a furyl, vii) a thienyl, viii) an oxazolyl, ix) an isoxazolyl, or x) an isothiazolyl

Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFα in human whole blood, the binding affinity