290309-72-7

Upstream product

• 290309-71-6 {2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-4,5-dimethoxy-phenyl}-acetaldehyde 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 312325-87-4 3-{2-[8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-4,5-dimethoxy-phenyl}-propane-1,2-diol 
• 290309-56-7 3-(2-allyl-4,5-dimethoxyphenyl)-8-benzyloxy-7-methoxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 290309-73-8 3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-8-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Electrophilic aromatic substitution by use of N-tosyliminium ions; elaboration of 3-aryl tetrahydroisoquinolines

The elaboration of 3-aryltetrahydroisoquinoline derivatives by electrophilic aromatic substitution of polysubstituted phenols and phenyl ethers with Lewis acid-generated tosyliminium ions is reported.

A tosyliminium ion-based total synthesis of (±)-schefferine

The synthesis of the phenolic tetrahydroprotoberberine alkaloid (±)-schefferine is reported, featuring as key steps a tosyliminium ion-mediated Friedel-Crafts alkylation of eugenol dimethyl ether and an intramolecular Mitsunobu-type amination.