290326-06-6

Upstream product

• 7703-74-4 2,6-bis-(bromomethyl)pyridine 
• 210303-79-0 N¹,N³,N⁵-tris(2-nitrobenzenesulfonyl)-1,5-diamino-3-azapentane 
• 657427-16-2 N,N-bis(2-hydroxyethyl)-o-nitrobenzenesulfonamide 
• 455890-94-5 N,N-bis(2-chloroethyl)-2-nitrobenzenesulfonamide 
• 34984-16-2 2,6-bis(aminomethyl)pyridine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 78668-34-5 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-triene 

Relevant academic research and scientific papers

Method for preparing 1,4,7,10-tetraaza-2,6-pyridinophane

The invention relates to a novel method for preparing 1,4,7,10-tetraaza-2,6-pyridinophane. 2,6-dimethylamino pyridine serving as a raw material is subjected to amino protection through o-/p-nitrobenzenesulfonyl and reacts with N,N-di(2-chloroethyl)-o-/p-n

Regioselective synthesis of N-functionalized 12-membered azapyridinomacrocycles bearing trialkylcarboxylic acid side chains

Selective protection of primary amine moieties of diethylenetriamine by 2-nitrophenylsulfonyl chloride followed by alkylation of the central N atom generates functionalized disulfonamide building blocks. When reacted with 2,6-bis(bromomethyl)pyridine following the Richman-Atkins methodology, such compounds yield the corresponding pyridine-containing azamacrocycles. Smooth removal of the N-sulfonyl groups provides versatile azamacrocyclic intermediates with transannular secondary amine functions. Subsequent N-alkylation regioselectively leads to tri N-functionalized 12-membered azapyridinomacrocycles bearing a sequence of N-acetate and N-propionate side chains.

A highly chemoselective protection and activation of primary amines in polyamine

Functionalization of polyamines containing both primary and secondary amine moieties could be achieved with the use of 2-nitrobenzenesulfonyl chloride. In the presence of a secondary amine, the primary amine groups are selectively transformed into the cor

An efficient synthesis of pyridine containing triaza-macrocyclic triacetate ligand and luminescence properties of its europium(III) complex

Reaction of diethylenetriamine with 2-nitrobenzenesulfonyl chloride leads to an activated and protected compound that could be cyclized to N-protected aza-macrocycle. After a smooth deprotection step, the macrocycle was alkylated with chloroacetic acid le