290331-05-4

Basic information

• Product Name: 4-chloro-N-(2,5-difluorophenyl)benzenesulfonamide
• Synonyms: 4-chloro-N-(2,5-difluorophenyl)benzenesulfonamide;4-chloro-N-[5-fluoro-2-fluorophenyl]benzenesulfonaMide
• CAS NO: 290331-05-4
• Molecular Formula: C₁₂H₈ClF₂NO₂S
• Molecular Weight: 303.72
• Mol File: 290331-05-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-N-(2,5-difluorophenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(2,5-difluorophenyl)benzenesulfonamide(290331-05-4)
• EPA Substance Registry System: 4-chloro-N-(2,5-difluorophenyl)benzenesulfonamide(290331-05-4)

Safety Data

• Hazardous Substances Data: 290331-05-4(Hazardous Substances Data)

Upstream product

• 367-30-6 2,5-difluoroaniline 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 909124-20-5 N-{1-[2-(3-bromo-propoxy)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide 
• 920012-12-0 N-{1-[4-benzoyl-2-(3-bromo-propoxy)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide 
• 909124-91-0 N-{1-[2-(3-bromo-propoxy)-4-(4-hydroxymethyl-benzoyl)-phenyl]-ethyl}-4-chloro-N-(2,5-difluoro-phenyl)-benzenesulfonamide 
• 920012-41-5 carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester 
• 865620-65-1 3-(2-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-thiazol-5-yl)-propionic acidmethyl ester 

Relevant articles and documents

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The synthesis and γ-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Aβ in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.

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