290357-28-7

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 290357-27-6 2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole 

Downstream Products

• 497165-51-2 2,3,5,6-Tetrafluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-pyridine 
• 497165-52-3 3,5-difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-pyridine-2,6-diamine 

Relevant academic research and scientific papers

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 Map kinase inhibitors

The 4-hydroxypiperidine substituent was found to confer high p38 selectivity devoid of COX-1 affinity, when attached to a series of pyridinyl substituted heterocycles. Pyridinyloxazole 11 showed a promising in vivo profile with bioavailability of 64% and