497165-52-3

Upstream product

• 290357-28-7 4-[5-bromo-2-(4-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-3-yl]-pyridine 
• 700-16-3 Pentafluoropyridine 
• 497165-51-2 2,3,5,6-Tetrafluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-pyridine 

Relevant academic research and scientific papers

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

2,6-Diamino-3,5-difluoropyridinyl substituted pyridinylimidazoles, -pyrroles, -oxazoles, -thiazoles and -triazoles have been identified as novel p38alpha inhibitors. Pyridinylimidazole 11 potently inhibited LPS-induced TNFalpha in mice, showed good efficacy in the established rat adjuvant (ED(50): 10 mg/kg po b.i.d.) and collagen induced arthritis (ED(50): 5 mg/kg po b.i.d.) with disease modifying properties based on histological analysis of the joints.