29039-60-9

Upstream product

• 3584-84-7 5-nitro-2-(trichloromethyl)-1H-benzo[d]imidazole 
• 64-17-5 ethanol 
• 95-92-1 oxalic acid diethyl ester 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 924-44-7 glyoxylic acid ethyl ester 

Downstream Products

• 294174-62-2 5-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H-benzoimidazole-2-carboxylic acid ethyl ester 
• 294174-46-2 5-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H-benzoimidazole-2-carboxylic acid 
• 866826-97-3 1-(2-fluoro-benzyl)-5-nitro-1H-benzoimidazole-2-carboxylic acid phenylamide 
• 866827-28-3 5-amino-1-(2-fluoro-benzyl)-1H-benzoimidazole-2-carboxylic acid phenylamide 

Relevant academic research and scientific papers

Rationalization of benzazole-2-carboxylate versus benzazine-3-one/ benzazine-2,3-dione selectivity switch during cyclocondensation of 2-aminothiophenols/phenols/anilines with 1,2-biselectrophiles in aqueous medium

The cyclocondensation reaction of 2-aminothiophenols with 1,2-biselectrophiles such as ethyl glyoxalate and diethyl oxalate in aqueous medium leads to the formation of benzothiazole-2-carboxylates via the 5-endo-trig process contrary to Baldwin's rule. On the other hand, the reaction of 2-aminophenols/anilines produced the corresponding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Baldwin's rule. The mechanistic insights of these cyclocondensation reactions using the hard-soft acid-base principle, quantum chemical calculations (density functional theory), and orbital interaction studies rationalize the selectivity switch of benzothiazole-2-carboxylates versus benzazine-3-ones/ benzazine-2,3-diones. The presence of water facilitates these cyclocondensation reactions by lowering of the energy barrier.

SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Synthesis and biological evaluation of novel n' (4-Aryloxybenzylidene)- 1h-Benzimidazole-2 carbohydrazide derivatives as anti-Tubercular agents

A series of structurally novel, (E)-N'-(4-Aryloxybenzylidene)-1H- Benzimidazole-2-Carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using R

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. We report systematic optimization of this compound class by means of classical and solid-phase chemistry. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE.