2904-95-2Relevant academic research and scientific papers
An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction
Ollevier, Thierry,Nadeau, Etienne
, p. 3126 - 3134 (2008/04/01)
In the presence of a catalytic amount of Bi(OTf)3·4H 2O, aldehydes together with amines react with silyl enolates to afford the corresponding Mannich-type adducts smoothly. A wide variety of silyl enolates derived from ketones, as well as esters and thioesters, react rapidly to afford the β-amino ketones or the β-amino esters in high yields (up to 94%). The Royal Society of Chemistry.
Stereoselective synthesis of syn-β-amino esters using the TiCl 4/R3N reagent system
Periasamy, Mariappan,Suresh, Surisetti,Subramaniapillai, Selva Ganesan
, p. 5521 - 5524 (2007/10/03)
The reactions of benzaldehyde imines and esters with the TiCl 4/R3N reagent system give syn-β-amino esters as the major products in 38-87% yields.
Bronsted Acid-Catalyzed Mannich-Type Reactions in Aqueous Media
Akiyama, Takahiko,Takaya, Jim,Kagoshima, Hirotaka
, p. 338 - 347 (2007/10/03)
HBF4-catalyzed Mannich-type reaction of silyl enolates with aldimines took place smoothly in aqueous organic solvent to afford β-aminocarbonyl compounds in high yields. The HBF4-catalyzed Mannich-type reaction also proceeded smoothly
HBF4 catalyzed Mannich-type reaction in aqueous media
Akiyama, Takahiko,Takaya, Jun,Kagoshima, Hirotaka
, p. 1045 - 1048 (2007/10/03)
HBF4 catalyzed Mannich-type reaction took place smoothly in aqueous media to afford β-amino carbonyl compounds in high yields. One-pot synthesis of β-amino carbonyl compounds from aldehyde and amine also worked well.
One-pot Mannich-type reaction in water: HBF4 catalyzed condensation of aldehydes, amines, and silyl enolates for the synthesis of β-amino carbonyl compounds
Akiyama, Takahiko
, p. 1426 - 1428 (2007/10/03)
HBF4 catalyzed Mannich-type reactions of aldehydes, amines, and silyl enolates took place smoothly in water in the presence of a surfactant to afford β-amino carbonyl compounds in high yields. Thieme Stuttgart.
DIASTEREOSELECTION IN TRIMETHYLSILYL TRIFLUOROMETHANESULPHONATE CATALYZED REACTION OF SILYL KETENE ACETALS WITH IMINES
Guanti, Giuseppe,Narisano, Enrica,Banfi, Luca
, p. 4331 - 4334 (2007/10/02)
The trimethylsilyl trifluoromethanesulphonate catalyzed condensation of silyl ketene acetals with imines afforded β-amino esters with prevalent anti relative diastereoselectivity (up to 100percent).Some anti β-amino esters have been then cyclized to trans
