2906-23-2

Basic information

• Product Name: [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid
• Synonyms: [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid;CDP-glucose
• CAS NO: 2906-23-2
• Molecular Formula: C15H25N3O16P2
• Molecular Weight: 0
• Mol File: 2906-23-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 909°C at 760 mmHg
• Flash Point: 503.6°C
• Appearance: /
• Density: 2.31g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.787
• CAS DataBase Reference: [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid(2906-23-2)
• EPA Substance Registry System: [5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[hydroxy-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phosphoryl]oxy-phosphinic acid(2906-23-2)

Safety Data

• Hazardous Substances Data: 2906-23-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H25N3O16P2/c16-7-1-2-18(15(25)17-7)13-11(23)9(21)6(31-13)4-30-35(26,27)34-36(28,29)33-14-12(24)10(22)8(20)5(3-19)32-14/h1-2,5-6,8-14,19-24H,3-4H2,(H,26,27)(H,28,29)(H2,16,17,25)

Upstream product

• 99-20-7 TREHALOSE 
• 63-38-7 cytidine diphosphate 
• 65-47-4 cytidine triphosphate 
• 59-56-3 α-D-glucopyranosyl-1-phosphate 
• 6757-06-8 cytidine-5'-monophosphate disodium salt 
• 57-50-1 Sucrose 

Downstream Products

• 21870-27-9 cytidylyldiphosphate-3,6-dideoxy-D-glycero-4-hexulose 
• 65207-55-8 D-lactal 

Relevant articles and documents

Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from: Streptococcus pneumonia serotype 23F

Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate-l-rhamnose (dTDP-Rha) biosynthetic pathway. In this study, the broad substrate specificity of Cps23FL towards six glucose-1-phosphates and nine nucleoside triphosphates as substrates was systematically explored, eventually providing access to nineteen sugar nucleotide analogs.

Exploiting nucleotidylyltransferases to prepare sugar nucleotides

(Graph Presented) Enzymatic approaches to prepare sugar nucleotides are gaining in importance and offer several advantages over chemical synthesis including high yields and stereospecificity. We report the cloning, expression, and purification of two new wild-type thymidylyltransferases and observed catalysis with a wide variety of substrates. Significant product inhibition was not observed with the enzymes studied over a 24 h period, enabling the efficient preparation of 15 sugar nucleotides, clearly demonstrating the synthetic utility of these biocatalysts.