57-50-1Relevant articles and documents
1H NMR spectroscopy-guided isolation of new sucrose esters from Physalis alkekengi var. franchetii and their antibacterial activity
Zhang, Chuan-Yang,Luo, Jian-Guang,Liu, Rui-Huan,Lin, Ru,Yang, Ming-Hua,Kong, Ling-Yi
, p. 138 - 143 (2016)
Ten new sucrose esters, physakengoses A–J (1???10), were isolated from the aerial parts of Physalis alkekengi var. franchetii under the guidance of 1H NMR spectroscopy. Their structures were determined by spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ESIMS) and chemical methods. These new compounds were tested for antibacterial activities against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. Among them, compounds 2 and 5–8 showed potent inhibitory effects against test strains with MIC values ranging from 3.5 to 14.9?μg/mL. These findings may indicate that the P. alkekengi var. franchetii has potential application as an ingredient in pharmaceuticals.
-
Mitra,Perlin
, p. 1079,1081 (1957)
-
Physakengoses K-Q, seven new sucrose esters from Physalis alkekengi var. franchetii
Zhang, Chuan-Yang,Luo, Jian-Guang,Liu, Rui-Huan,Lin, Ru,Yang, Ming-Hua,Kong, Ling-Yi
, p. 120 - 124 (2017)
Seven sucrose esters, physakengoses K-Q (1–7) were isolated from the aerial parts of Physalis alkekengi var. franchetii. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. These new compounds were teste
Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity
Ban, Ninh Khac,Doan, Vu Van,Kiem, Phan Van,Kim, Seung Hyun,Namkung, Wan,Nhiem, Nguyen Xuan,Seo, Yohan,Tai, Bui Huu,Tiep, Tran Van,Truong, Luu Hong,Yen, Duong Thi Hai
, (2020)
Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 μM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10percent, 35.6 ± 0.92percent, 43.7 ± 1.61percent, and 40.8 ± 1.25percent, respectively.
Peruvioses A to F, sucrose esters from the exudate of Physalis peruviana fruit as α-amylase inhibitors
Bernal, Carlos-A.,Castellanos, Leonardo,Aragón, Diana M.,Martínez-Matamoros, Diana,Jiménez, Carlos,Baena, Yolima,Ramos, Freddy A.
, p. 4 - 10 (2018)
The fruit of Physalis peruviana is widely used in traditional Colombian medicine as an antidiabetic treatment. The aim of the study reported here was to identify the compounds responsible for the hypoglycemic activity using the α-amylase inhibition test. Bioguided fractionation of a dichloromethane extract of the sticky exudate that covers the fruit allowed the isolation and identification of three new sucrose esters, named as peruvioses C–E (1–3), along with the known peruvioses A (6), B (5) and F (4), the structures of which were elucidated by extensive NMR and MS experiments. These compounds proved to be responsible for the hypoglycemic activity observed in the extract. Peruviose D (2) showed the highest activity, with an inhibitory activity value of 84.8%. This is the first study to establish the potential of sucrose esters as α-amylase inhibitors and to explain the hypoglycemic effect that has traditionally been attributed to gooseberry fruit.
ANTI-VIRAL COMPOUNDS AND METHODS OF USE
-
, (2021/12/29)
The present disclosure relates to compounds and compositions for use in treating disease, such as viral infection. As disclosed herein, the compounds include an “NMN-like” moiety linked to another moiety with biological activity upon administration. In some cases, the disease to be treated is infection with viruses. Such viruses include coronaviruses, such as SARS, MERS, or COVID-19, HIV, and viruses associated with hepatitis. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD) in cells and tissues for treating diseases and/or improving cell and tissue survival.
Safe and Effective Method of Treating Ulcerative Colitis with Anti-IL12/IL23 Antibody
-
, (2020/04/10)
Described are methods and compositions for clinical proven safe and effective treatment of ulcerative colitis, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.
