29078-50-0Relevant academic research and scientific papers
Substituted benzothieno [2,3-c] tetrahydropyridine derivative and preparation method and application thereof
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Paragraph 0055; 0056; 0059; 0062, (2018/07/30)
The invention belongs to the technical field of medicinal chemistry and medicines, and relates to a substituted benzothieno [2,3-c] tetrahydropyridine derivative as shown in formula (I), a preparationmethod of the substituted benzothieno [2,3-c] tetrahydr
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors
Wang, Mingliang,Fang, Yanjia,Gu, Shoulai,Chen, Fangfang,Zhu, Zhengjiang,Sun, Xun,Zhu, Jidong
, p. 157 - 172 (2017/03/31)
The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure–activity relationship (SAR) study for a series of novel 1,2,3,4- tetrahydroben
