29079-97-8

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 141-82-2 malonic acid 

Downstream Products

• 1036226-96-6 3-[5-(4-trifluoromethoxy-phenyl)-thiophen-2-yl]-acrylic acid 
• 929975-30-4 3-[5-(4-fluoro-phenyl)-thiophen-2-yl]-acrylic acid 
• 949977-46-2 3-[5-(2-fluoro-phenyl)-thiophen-2-yl]-acrylic acid 
• 950094-47-0 3-[5-(4-chloro-phenyl)-thiophen-2-yl]-acrylic acid 
• 1454891-02-1 (E)-3-(5-bromothiophen-2-yl)-N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)acrylamide 
• 28948-60-9 2-bromothieno[3,2-c]pyridin-4(5H)-one 
• 1333107-73-5 C₂₁H₁₆N₄O₃S₂ 
• 1333107-72-4 C₂₀H₁₇N₃O₃S₂ 
• 1333107-85-9 C₂₁H₁₇N₃O₂S 
• 1333107-84-8 C₁₉H₁₃FN₂O₂S 
• 1333107-82-6 C₂₀H₁₆N₂O₂S 
• 1333107-79-1 C₂₀H₁₃N₃OS 
• 1333107-77-9 C₁₉H₁₀FN₃OS 

Relevant academic research and scientific papers

PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE

The present invention deals with new flavivirus inhibitors, compositions comprising said inhibitors and methods for the treatment of disorders related to a viral infection, such as a disease due to a flavivirus infection, comprising administering said inhibitors.

Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity

Two new series of new compounds containing a 6-amino-substituted group or 6-acrylamide-substituted group linked to a 4-anilinoquinazoline nucleus have been discovered as potential EGFR inhibitors. These compounds proved efficient effects on antiproliferative activity and EGFR-TK inhibitory activity. Especially, N6-((5-bromothiophen-2-yl)methyl)-N4-(3- chlorophenyl)quinazoline-4,6-diamine (5e), showed the most potent inhibitory activity (IC50 = 3.11 μM for Hep G2, IC50 = 0.82 μM for A549). The EGFR molecular docking model suggested that the new compound is nicely bound to the region of EGFR, and cell morphology by Hoechst stain experiment suggested that these compounds efficiently induced apoptosis of A549 cells.

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors

The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3β inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.

Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase

The present invention relates to heteroaryl-substituted carboxamides of the formula I, in which Het, A, X, R1, R2 and R3 have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxi