290831-98-0Relevant academic research and scientific papers
2-Aryl indole NK1 receptor antagonists: Optimisation of the 2-aryl ring and the indole nitrogen substituent
Dinnell, Kevin,Chicchi, Gary G.,Dhar, Madhumeeta J.,Elliott, Jason M.,Hollingworth, Gregory J.,Kurtz, Marc M.,Ridgill, Mark P.,Rycroft, Wayne,Tsao, Kwei-Lan,Williams, Angela R.,Swain, Christopher J.
, p. 1237 - 1240 (2007/10/03)
Novel 2-aryl indole hNK1 receptor ligands were prepared utilising palladium cross-coupling chemistry of a late intermediate as a key step. Compounds with high hNK1 receptor binding affinity and good brain penetration (e.g., 9d) were synthesised.
