5464-78-8

Basic information

• Product Name: 1-(2-Methoxyphenyl)piperazine hydrochloride
• Synonyms: LABOTEST-BB LT00159868;1-(2-METHOXYPHENYL)PIPERAZINE HYDROCHLORIDE;1-(2-METHOXYPHENYL)-PEPIPAZINE HCL;1-(2-METHOXYPHENYL)PIPERAZINE DIHYDROCHLORIDE;TIMTEC-BB SBB003293;O-METHOXYPHENYL PIPERAZINE HYDROCHLORIDE;1-(2-methoxyphenylj-piperazinemonohydrochloride;1-(2-methoxyphenyl)piperazinium chloride
• CAS NO: 5464-78-8
• Molecular Formula: C11H17ClN2O
• Molecular Weight: 228.71848
• EINECS: 226-762-6
• Product Categories: Piperazines;Heterocycles;Piperidines, Piperidones, Piperazines;PiperazineDerivative;Piperaizine;Piperazine derivates;Heterocyclic Compounds;(intermediate of naftopidil);Aromatics;Building Blocks;Heterocyclic Building Blocks
• Mol File: 5464-78-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 217-219 °C(lit.)
• Boiling Point: 130-133C
• Flash Point: 154 °C
• Appearance: off-white solid
• Density: 1.106g/cm
• Vapor Pressure: 5.68E-06mmHg at 25°C
• Refractive Index: 1,574-1,576
• Storage Temp.: -20°C Freezer
• Solubility: Soluble in DMSO and Methanol.
• Sensitive: Hygroscopic
• BRN: 4276925
• CAS DataBase Reference: 1-(2-Methoxyphenyl)piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxyphenyl)piperazine hydrochloride(5464-78-8)
• EPA Substance Registry System: 1-(2-Methoxyphenyl)piperazine hydrochloride(5464-78-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-28A
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 5464-78-8(Hazardous Substances Data)

Usage

Chemical Properties

1-(2-Methoxyphenyl)piperazine hydrochloride is Off-White Solid

Uses

Different sources of media describe the Uses of 5464-78-8 differently. You can refer to the following data:
1. 1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories.
2. 1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories. It is used in chemical synthesis studies.

InChI:InChI=1/C11H16N2O.ClH/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;/h2-5,12H,6-9H2,1H3;1H

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 90-04-0 2-methoxy-phenylamine 
• 578-57-4 2-bromoanisole 
• 95520-98-2 tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate 

Downstream Products

• 780028-85-5 1-(5-chlorobenzo[b]thiophen-3-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one 
• 219907-62-7 1-(benzo[b]thiophen-3-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one 
• 172752-02-2 3-<4-(2-methoxyphenyl)piperazino>propiophenone 
• 328248-34-6 1-(4-methoxy-phenyl)-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propan-1-one 
• 102391-85-5 2‐{3‐[4‐(2‐methoxyphenyl)piperazin‐1‐yl]propyll}isoindoline‐1,3‐dione 
• 102392-05-2 2-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-isoindole-1,3-dione 
• 40004-60-2 1-(2-hydroxyethyl)-4-(2-methoxyphenyl)piperazine 
• 901124-79-6 8-bromo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine 
• 901124-80-9 8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine 
• 841246-22-8 2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-benzonitrile 
• 154060-79-4 3-<<<4-(2-methoxyphenyl)-1-piperazinyl>methyl>phenyl>benzenenitrile 
• 560117-77-3 4-(4-(2-methoxyphenyl)piperazin-1-ylmethyl)benzonitrile 

Relevant articles and documents

Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors

Rational drug design method has been used to generate 4-arylpiperazine carboxamides in an effort to develop safer, more potent and effective monoamine neurotransmitters reuptake inhibitors. Out of twenty-seven synthesized compounds, compound 9 displayed potent monoamine neurotransmitter reuptake inhibitory activity against HEK cells transfected with hSERT or hNET. A Surflex-Dock docking model of 9 was also studied.

Exploration of substituted arylpiperazine–tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors

In the search for potent dual norepinephrine and dopamine reuptake inhibitors, several substituted arylpiperazine–tetrazoles were designed, synthesized and evaluated for their neurotransmitter reuptake inhibitory activities. Various derivatives exhibited selective and strong neurotransmitter reuptake inhibitory activity. In particular, compounds with a three-carbon linker displayed selective and stronger potency than those with two-carbon and four-carbon linkers. Interestingly, six compounds, 9b, 9c, 9d, 9o, 9q and 9u displayed more effective activity than the standard drug, bupropion. The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases.

FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS

The present invention relates to novel functionally selective ligands of dopamine D2 receptors, including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.