2910-76-1

Upstream product

• 102-92-1 cinnamoyl chloride 
• 95-48-7 ortho-cresol 
• 621-82-9 Cinnamic acid 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 100-52-7 benzaldehyde 
• 65081-22-3 trans-cinnamic acid o-tolyl ester 

Downstream Products

• 1092962-17-8 amino-3-(4-hydroxy-3-methylphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-ylmethanethione 
• 934736-13-7 2-methyl-4-(5'-phenyl-4,5-dihydro-1H-3-pyrazolyl)phenol 

Relevant academic research and scientific papers

NIR optical carbon dioxide sensors based on highly photostable dihydroxy-aza-BODIPY dyes

A new class of pH-sensitive indicator dyes for optical carbon dioxide sensors based on di-OH-aza-BODIPYs is presented. These colorimetric indicators show absorption maxima in the near infrared range (λmax 670-700 nm for the neutral form, λmax 725-760 nm for the mono-anionic form, λmax 785-830 nm for the di-anionic form), high molar absorption coefficients of up to 77 000 M-1 cm-1 and unmatched photostability. Depending on the electron-withdrawing or electron-donating effect of the substituents the pKa values are tunable (8.7-10.7). Therefore, optical carbon dioxide sensors based on the presented dyes cover diverse dynamic ranges (0.007-2 kPa; 0.18-20 kPa and 0.2-100 kPa), which enables different applications varying from marine science and environmental monitoring to food packaging. The sensors are outstandingly photostable in the absence and presence of carbon dioxide and can be read out via absorption or via the luminescence-based ratiometric scheme using the absorption-modulated inner-filter effect. Monitoring of the carbon dioxide production/consumption of a Hebe plant is demonstrated.

Tautomeric origin of dual effects of N1-nicotinoyl-3-(4′-hydroxy- 3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines on bacterial and viral strains: POM analyses as new efficient bioinformatics' platform to predict and optimize bioactivity of drugs

In this study, we have amalgamated computational methodologies, viz. Petra, Osiris and Molinspiration (POM) to identify pharmacophores and antipharmacophores for antibacterial/antiviral activities of some 2-pyrazolines derivatives. Lipophilicity and the p

Selective synthesis of 3,4-dihydrocoumarins and chalcones from substituted aryl cinnamic esters

Coumarins are ubiquitous in plant kingdom and have been used as antitumor, antifungals, anticoagulants, insecticides. Chalcones are also widespread in plant kingdom and have been known to possess diverse biological activities; antibacterial, antifungal, antitumor and anti-inflammatory, etc. As they are considered as important natural products, numerous synthetic approaches have been reported up to the present. We devise a new selective method of preparing dihydrocoumarins and chalcones from aryl cinnamates by the selection of reagents. Dihydrocoumarin derivatives were prepared selectively by using intramolecular cyclization catalyzed by p-toluene sulfonic acid. Also, chalcones were prepared by Fries-rearrangement catalyzed by TiCl4. This method can be used for preparing various coumarin & chalcone compounds.

Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives

In the present investigation, a series of 5-(-4-(substituted) phenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted) phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxyanilino me

Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino m

Synthesis and antimycobacterial activity of novel 4-[5-(substituted phenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol derivatives

In the present investigation, 4-hydroxy-3-methylacetophenone, on condensation with appropriate aldehydes in methanolic potassium hydroxide solution, yielded the corresponding chalcones (CI-XI). These corresponding chalcones were reacted with ph

Synthesis of novel substituted pyrazolyl-2-toluidinomethanethione and pyrazolyl-2-methoxyanilinomethanethione as potential antitubercular agents

In the present investigation, a series of 5-[(substituted) phenyl]-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2- toluidinomethanethione and 5-[(substituted) phenyl]-3-(4-hydroxy-3-methylphenyl) -4,5-dihydro-1H-1-pyrazolyl-2-methoxyanilinometh

Synthesis and anti-HIV activity of N1-nicotinoyl - 3-(4′-hydroxy-3′-methylphenyl)-5-[substituted phenyl] - 2-pyrazolines

A series of N1-nicotinoyl-3-(4′-hydroxy-3′- methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c)

Synthesis and in-vitro antimycobacterial activity of amino-5-[(substituted) phenyl]-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolylmethanethione

A series of amino-5-[(substituted) phenyl]-3-(4-hydroxy-3-methylphenyl)-4, 5-dihydro-1H-1-pyrazolylmethanethione were synthesized by the reaction between thiosemicarbazide and chalcones and were tested for their antimycobacterial activity in vitro against

Synthesis and in vitro antimycobacterial activity of N1-nicotinoyl-3-(4′-hydroxy-3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines

A series of N1-nicotinoyl-3- (4′-hydroxy-3′-methyl phenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their antimycobacterial activity in vitro against Mycobac