29106-16-9

Upstream product

• 308796-10-3 (1-pentyl)zinc(II) bromide 
• 1057662-85-7 (E)-2-(3,7-dimethylocta-2,6-dien-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 112639-16-4 2-iodo-1,3-dimethoxy-5-pentylbenzene 
• 6138-90-5 trans-geranyl bromide 
• 1309372-75-5 2-(2,6-dimethoxy-4-pentylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 25654-31-3 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol 
• 74-88-4 methyl iodide 
• 22976-40-5 1,3-dimethoxy-5-pentylbenzene 
• 83036-59-3 geranyl diisopropyl phosphate 

Relevant academic research and scientific papers

CATALYTIC CANNABIGEROL PROCESSES AND PRECURSORS

The present disclosure relates to cannabigerol sulfonate esters and processes for their use to prepare cannabigerol (CBG) and related compounds, including cannabigerobutol (CBGB), cannabigerovarin (CBGV), and cannabigerophorbol (CBGP). In a preferred embodiment, the cannabigerol sulfonate ester is (E)-4-(3, 7-5 dimethylocta-2,6-dienyl)-3,5-bis(trimetbylsilyloxy)phenyl trifluoromethanesulfonate. In a preferred process, the trifluoromethansulfonate leaving group is replaced by an alkyl group. The disclosure also relates to the use of catalysts and catalytic processes for the preparation of cannabigerol and related compounds from the cannabigerol sulfonate esters.

SYNTHESIS OF CANNABIGEROL

Multiple methods of synthesizing cannabigerol are presented. Combining olivetol with geraniol derivatives are provided. Cross-coupling methods of combing functionalized resorcinols are provided. Useful intermediates are formed during such cross-coupling steps.

Base-catalysed Double-bond Isomerizations of Cannabinoids: Structural and Stereochemical Aspects

Base-catalysed double-bond isomerization offers a convenient, high-yield route to a variety of new cannabinoids, as well as to compounds of this group which are accessible with some difficulty.By this route we have obtained optically active Δ2-

AN EFFICIENT REGIO- AND STEREOSPECIFIC ALKENYLATION OF PHENOLIC ETHERS BY PRENYL AND GERANYL DIISOPROPYL PHOSPHATES

Prenyl and geranyl diisopropyl phosphates readily alkenylate a variety of phenolic ethers regio- and stereospecifically without any appreciable side reactions.