29121-34-4

Basic information

• Product Name: Benzeneacetamide, 4-hydroxy-N-methyl-
• Synonyms: Benzeneacetamide, 4-hydroxy-N-methyl-;2-(p-Hydroxyphenyl)-N-methylacetamide;4-Hydroxy-N-methylbenzeneacetamide;2-(4-Hydroxyphenyl)-N-methylacetamide;4-Hydroxy-N-methyl-benzeneacetamide（WS203225）
• CAS NO: 29121-34-4
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165
• Mol File: 29121-34-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 124-125℃
• Appearance: /
• Density: 1.154
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzeneacetamide, 4-hydroxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, 4-hydroxy-N-methyl-(29121-34-4)
• EPA Substance Registry System: Benzeneacetamide, 4-hydroxy-N-methyl-(29121-34-4)

Safety Data

• Hazardous Substances Data: 29121-34-4(Hazardous Substances Data)

Usage

General Description

Benzeneacetamide, 4-hydroxy-N-methyl- is a chemical compound that is also known as homoveratrylamine. It is a derivative of acetanilide and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has a hydroxyl group and a methyl group attached to the benzene ring, making it a versatile building block for the production of various drugs and active ingredients. It is important to handle this chemical with care and adhere to proper safety protocols due to its potential health hazards.

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 74-89-5 methylamine 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 

Downstream Products

• 29121-33-3 2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-N-methyl-acetamide 
• 13062-76-5 N-Methyltyramine hydrochloride 
• 29121-43-5 2-[3-Allyl-4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-N-methyl-acetamide 
• 29289-33-6 2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-3-propyl-phenyl]-N-methyl-acetamide 
• 47368-13-8 2-[3-Allyl-4-(3-tert-butylamino-2-hydroxy-propoxy)-phenyl]-N-methyl-acetamide 
• 29112-36-5 2-(3-Allyl-4-hydroxy-phenyl)-N-methyl-acetamide 
• 29112-38-7 2-(4-Allyloxy-phenyl)-N-methyl-acetamide 

Relevant articles and documents

Synthesis method of N-methyltyramine hydrochloride

The invention relates to a synthesis method of N-methyltyramine hydrochloride and belongs to the technical field of organic synthesis. The synthesis method comprises dissolving p-hydroxyphenylacetic acid in a solvent 1, adding thionyl chloride into the solution, carrying out reflux stirring for a complete reaction, cooling the product, adding the reaction solution into an aqueous solution of methylamine drop by drop, then carrying out thermal insulation stirring, filtering the mixture to obtain an intermediate, dissolving the intermediate in a solvent 2, adding a reducer into the solution at the room temperature, then adding Lewis acid into the solution in batches, carrying out heating reflux stirring overnight, after the reaction is finished, introducing the reaction solution into an acid solution, adjusting pH to 7, stirring the solution, carrying out filtration and liquid separation, feeding hydrogen chloride gas into the second layer of the solvent until the hydrogen chloride gas is saturated and pH of the solution is 1, carrying out stirring and then pumping filtration, and carrying out solid leaching and drying to obtain N-methyltyramine hydrochloride. The synthesis method has the advantages of mild reaction conditions, high conversion rate, cheap and easily available raw materials, use of cheap conventional reagents, low synthesis cost, simple and easy post-treatment, no generation of a large amount of three wastes, high product yield, high purity and good quality.

OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE

The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.

Process for substituted pyridines

This invention relates to processes for preparing compounds of the formula (I) and to processes for preparing certain intermediates of the formula wherein R1is nitro, amino or protected amino; R2is H, fluoro, chloro CF3, n