29126-12-3

Usage

InChI:InChI=1/C29H26N2O4S/c1-19-18-36-28-24(30-23(32)17-20-11-5-2-6-12-20)27(33)31(28)25(19)29(34)35-26(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,24,26,28H,17-18H2,1H3,(H,30,32)/t24-,28-/m1/s1

Upstream product

• 851-77-4 3-Methyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 544-97-8 dimethyl zinc(II) 
• 92096-37-2 benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-3-[(methylsulfonyl)oxy]-3-cephem-4-carboxylate 
• 41128-81-8 (6R,7R)-benzhydryl 3-(acetyloxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 851-77-4 3-Methyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

A facile synthesis of cephem side chains by palladium catalyzed cross- coupling of 3-substituted-δ3-cephems with dialkylzinc or vinyltributyltin

Synthesis of 3-vinyl- and 3-alkyl-Δ3-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Δ3-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Δ3-cephems is opened, starting from the allenyl compound 10.

A facile synthesis of 7-amino-3-desacetoxycephalosporanic acid derivatives by indium-mediated reduction of 3-iodomethylcephems in aqueous media

An efficient reductive conversion of 3-iodomethylcephalosporin and 3- acetoxymethylcephalosporin derivatives mediated by indium into the corresponding 3-methylcephems and 3-methylenecephams in moderate to good yields has been developed in an aqueous system. 3-Methylenecephams are converted into the corresponding 3-methylcephems under previously reported basic conditions quantitatively. (C) 2000 Elsevier Science Ltd.

N,N'-diisopropyl-O-diphenylmethyl isourea: A mild and convenient alklating agent for the formation of cephalosporin derivatives derivatives

N,N'-Diisopropyl-O-diphenylmethyl isourea reacts with cephalosporin-4- carboxylic acid in tetrahydrofuran at room temperature to give the diphenylmethyl (DPM) ester in good yields without isomerization of the double bond from C-3 to C-2.