A facile synthesis of cephem side chains by palladium catalyzed cross- coupling of 3-substituted-δ3-cephems with dialkylzinc or vinyltributyltin

Article abstract of DOI:10.1016/S0040-4039(98)01940-6

Synthesis of 3-vinyl- and 3-alkyl-Δ³-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Δ³-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Δ³-cephems is opened, starting from the allenyl compound 10.