291275-46-2

Basic information

• Product Name: (R)-1-(3-Chlorophenyl)-2-hydroxy-1-propanone
• Synonyms: (R)-1-(3-Chlorophenyl)-2-hydroxy-1-propanone
• CAS NO: 291275-46-2
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Product Categories: Aromatics;Intermediates;Aromatics, Intermediates
• Mol File: 291275-46-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Ethyl Accetate, Methanol
• CAS DataBase Reference: (R)-1-(3-Chlorophenyl)-2-hydroxy-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3-Chlorophenyl)-2-hydroxy-1-propanone(291275-46-2)
• EPA Substance Registry System: (R)-1-(3-Chlorophenyl)-2-hydroxy-1-propanone(291275-46-2)

Safety Data

• Hazardous Substances Data: 291275-46-2(Hazardous Substances Data)

Upstream product

• 75-07-0 acetaldehyde 
• 587-04-2 m-Chlorobenzaldehyde 
• 376346-55-3 rac-1-(3-chlorophenyl)-2-acetoxypropan-1-one 
• 34841-35-5 3'-chloro-propiophenone 
• 291275-45-1 (Z)-tert-butyl-[1-(3-chlorophenyl)prop-1-enyloxy]dimethylsilane 

Downstream Products

• 291275-48-4 Trifluoro-methanesulfonic acid (R)-2-(3-chloro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 1231951-92-0 (2S,3S)-2-(3-chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol 
• 192374-14-4 radafaxine 
• 497239-91-5 (2R,3S)-3-(3-chlorophenyl)pent-4-ene-2,3-diol 
• 1335239-49-0 (1S,2R)-1-(3-chlorophenyl)propane-1,2-diol 
• 1335239-62-7 (1R,2R)-1-(3-chlorophenyl)propane-1,2-diol 

Relevant articles and documents

Asymmetric α-hydroxy ketone synthesis by direct ketone oxidation using a bimetallic palladium(II) complex

The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF-water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee's ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE

The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.

Biocatalytic racemization of synthetically important functionalized α-hydroxyketones using microbial cells

Biocatalytic racemization of straight-chain and cyclic acyloins bearing (halo)alkyl, alkenyl and functionalized (hetero)aryl moieties was accomplished using whole resting cells of bacteria, fungi and yeasts. Mild physiological reaction conditions ensured the suppression of undesired side-reactions, such as elimination or condensation. This biocatalytic protocol represents a useful tool for the clean racemization of unwanted enantiomers of synthetically important α-hydroxyketones derived from kinetic resolution.