376346-55-3Relevant academic research and scientific papers
Biocatalytic racemization of synthetically important functionalized α-hydroxyketones using microbial cells
Nestl, Bettina M.,Bodlenner, Anne,Stuermer, Rainer,Hauer, Bernhard,Kroutil, Wolfgang,Faber, Kurt
, p. 1465 - 1474 (2008/02/13)
Biocatalytic racemization of straight-chain and cyclic acyloins bearing (halo)alkyl, alkenyl and functionalized (hetero)aryl moieties was accomplished using whole resting cells of bacteria, fungi and yeasts. Mild physiological reaction conditions ensured the suppression of undesired side-reactions, such as elimination or condensation. This biocatalytic protocol represents a useful tool for the clean racemization of unwanted enantiomers of synthetically important α-hydroxyketones derived from kinetic resolution.
Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones
Demir, Ayhan S.,Hamamci, Haluk,Sesenoglu, Ozge,Aydogan, Feray,Capanoglu, Doga,Neslihanoglu, Rahsan
, p. 1953 - 1956 (2007/10/03)
A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.
