291279-17-9Relevant articles and documents
Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 1: Chloromethylation of N-protected 3-oxazolidin-5-ones
Onishi, Tomoyuki,Hirose, Naoko,Nakano, Takashi,Nakazawa, Masakazu,Izawa, Kunisuke
, p. 5883 - 5885 (2001)
Reaction of N-protected 3-oxazolidin-5-ones with in situ-generated chloromethyllithium afforded N-protected 5-chloromethyl-5-hydroxy-3-oxazolidines without racemization. They were easily hydrolyzed to give α-aminoalkyl-α′-chloromethylketone derivatives, which are useful intermediates for several protease inhibitors.
Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin
Matsuo, Takashi,Imai, Chie,Yoshida, Takefumi,Saito, Takashi,Hayashi, Takashi,Hirota, Shun
supporting information; experimental part, p. 1662 - 1664 (2012/03/27)
An l-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda-Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein. The Royal Society of Chemistry 2012.