2913-46-4

Upstream product

• 186581-53-3 diazomethane 
• 1760-68-5 2-hydroxy-5,6-dimethylcyclohexa-2,5-diene-1,4-dione 
• 67-56-1 methanol 
• 526-86-3 2,3-dimethyl-1,4-benzoquinone 
• 5091-02-1 1,2,5-triacetoxy-3,4-dimethyl-benzene 

Downstream Products

• 90534-59-1 1,6-Dihydroxy-1,2,3-trimethyl-cyclohexadien-(2,5)-on-⁽⁴⁾ 
• 90926-41-3 1-Hydroxy-4-methoxy-1,2,3-trimethyl-cyclohexadien-(2,4)-on-⁽⁶⁾ 
• 93734-86-2 5-Hydroxy-2.3.4-trimethyl-2'.4'-dinitro-azobenzol 
• 90926-42-4 1-Hydroxy-6-methoxy-1,2,3-trimethylcyclohexadien-(2,5)-on-⁽⁴⁾ 

Relevant academic research and scientific papers

A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26

The preparation of heteroatom-substituted p-quinones is ideally performed by direct addition of a nucleophile followed by in situ reoxidation. Albeit an appealing strategy, the reactivity of the p-quinone moiety is not easily tamed and no broadly applicable method for heteroatom functionalization exists. Shown herein is that Co(OAc)2 and Mn(OAc)3?2 H2O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S nucleophiles, using oxygen as the terminal oxidant. Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented.