291303-23-6

Basic information

• Product Name: (S)-2-(1,3-dioxoisoindolin-2-yl)-4-phenylbutanoic acid
• Synonyms: (S)-2-(1,3-dioxoisoindolin-2-yl)-4-phenylbutanoic acid
• CAS NO: 291303-23-6
• Molecular Weight: 309.321
• Mol File: 291303-23-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-(1,3-dioxoisoindolin-2-yl)-4-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1,3-dioxoisoindolin-2-yl)-4-phenylbutanoic acid(291303-23-6)
• EPA Substance Registry System: (S)-2-(1,3-dioxoisoindolin-2-yl)-4-phenylbutanoic acid(291303-23-6)

Safety Data

• Hazardous Substances Data: 291303-23-6(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 943-73-7 D-homophenylalanine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 200731-02-8 N-phthaloyl-L-(-)-4-oxo-homophenylalanine 
• 71-43-2 benzene 
• 16652-95-2 N²-phthalyl-L-aspartic anhydride 

Downstream Products

• 105382-09-0 L-(+)-homophenylalanine hydrochloride 

Relevant articles and documents

General Access to Modified α-Amino Acids by Bioinspired Stereoselective γ-C?H Bond Lactonization

α-Amino acids represent a valuable class of natural products employed as building blocks in biological and chemical synthesis. Because of the limited number of natural amino acids available, and of their widespread application in proteomics, diagnosis, drug delivery and catalysis, there is an increasing demand for the development of procedures for the preparation of modified analogues. Herein, we show that the use of bioinspired manganese catalysts and H2O2 under mild conditions, provides access to modified α-amino acids via γ-C?H bond lactonization. The system can efficiently target 1°, 2° and 3° γ-C?H bonds of α-substituted and achiral α,α-disubstituted α-amino acids with outstanding site-selectivity, good to excellent diastereoselectivity and (where applicable) enantioselectivity. This methodology may be considered alternative to well-established organometallic procedures.

The synthesis of L-(+)-homophenylalanine hydrochloride

L-(+)-Homophenylalanine hydrochloride was synthesized from N-phthaloyl-L-(-)-asparitc anhydride 2 in three steps in 55% overall yield with 99% ee. Copyright (C) 2000 Elsevier Science Ltd.