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Usage

Uses

Used in Organic Synthesis:
Pyridine, 5-bromo-2-(trimethylsilyl)is used as a building block for the creation of pharmaceuticals and agrochemicals. Its unique structure allows for the formation of carbon-carbon and carbon-heteroatom bonds, making it a valuable reagent in various chemical reactions.
Used in Chemical Reactions:
Pyridine, 5-bromo-2-(trimethylsilyl)is used as a reagent in chemical reactions, particularly for the formation of carbon-carbon and carbon-heteroatom bonds. Its presence enhances the reactivity and selectivity of the reactions, leading to the synthesis of desired products.
Used in Protective Group Chemistry:
The trimethylsilyl group in pyridine, 5-bromo-2-(trimethylsilyl)can serve as a protective group for alcohols and amines during chemical transformations. This feature allows chemists to selectively modify specific functional groups without affecting others, enabling the synthesis of complex organic molecules with high precision.
Used in Pharmaceutical Industry:
Pyridine, 5-bromo-2-(trimethylsilyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it suitable for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
Pyridine, 5-bromo-2-(trimethylsilyl)is also used in the agrochemical industry for the synthesis of pesticides and other agrochemicals. Its versatility in organic synthesis allows for the development of novel compounds with enhanced efficacy and selectivity in controlling pests and diseases in agriculture.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 75-77-4 chloro-trimethyl-silane 
• 223463-13-6 2-iodo-5-bromopyridine 

Relevant academic research and scientific papers

NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME

Provided are novel organic electroluminescent compounds and an organic electroluminescent device including the same. The disclosed organic electroluminescent compounds exhibit high luminescence efficiency in blue color and excellent life property. Thus, they may be used to manufacture OLEDs having very good operation life.

TMSCH2Li and TMSCH2Li-LiDMAE: Efficient reagents for noncryogenic halogen-lithium exchange in bromopyridines

(Chemical Equation Presented) TMSCH2Li and TMSCH 2Li-LiDMAE have been used efficiently for bromine-lithium exchange in 2-bromo-, 3-bromo-, and 2,5-dibromopyridines under noncryogenic conditions, while low temperatures (-78 to -100°C) are always needed with n-BuLi. The aminoalkoxide LiDMAE induced a remarkable C-2 selectivity with 2,5-dibromopyridines in toluene at 0°C, which was unprecedented at such a temperature. The lithiopyridines were successfully reacted witb electrophiles also under noncryogenic conditions giving the expected adducts in good yields.

Synthesis of 5-bromopyridyl-2-magnesium chloride and its application in the synthesis of functionalized pyridines

(Chemical Equation Presented) The 5-bromopyridyl-2-magnesium chloride (2), which was not accessible previously, was efficiently synthesized for the first time via an iodomagnesium exchange reaction with 5-bromo-2-iodopyridine (1). This reactive intermediate was allowed to react with a variety of electrophiles to afford a range of useful functionalized pyridine derivatives. Application of this methodology to 5-bromo-2-iodo-3-picoline provided a simple and economical synthesis of a key intermediate for the preparation of Lonafarnib, a potent anticancer agent.

Selective monolithiation of 2,5-dibromopyridine with butyllithium

Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favor the 5- position while non-coordinati