29138-64-5

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DIMETHYLBUTANOIC ANHYDRIDE is used as a synthetic intermediate for the preparation of Adamantylmethylamine derivatives. These derivatives serve as inhibitors of ATP-sensitive Potassium channels, which play a crucial role in the regulation of cellular processes such as insulin secretion and neuronal excitability. The inhibition of these channels can be beneficial in the development of pharmaceuticals targeting conditions like type 2 diabetes, epilepsy, and certain cardiovascular diseases.

InChI:InChI=1/C12H22O3/c1-7-11(3,4)9(13)15-10(14)12(5,6)8-2/h7-8H2,1-6H3

Upstream product

• 595-37-9 2,2-dimethylbutyric acid 

Downstream Products

• 136007-86-8 4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dimethyl-6-methyl>phenoxy>methyl>tetrahydropyran-2-one 
• 136007-85-7 4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dimethyl-6-methyl>phenoxy>methyl>tetrahydropyran-2-one 
• 145576-25-6 simvastatin acetate 
• 851402-85-2 bis-simvastatin 
• 210980-68-0 anhydrosimvastatin 
• 850920-00-2 C₂₃H₃₂O₆ 
• 81189-92-6 (S)-2-methyl-butyric acid (3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-acetoxy-6-oxo-tetrahydro-pyran-2yl]-ethyl}-3,7-dimetyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester 
• 851402-84-1 4-simvastain-8-lovastatin 
• 123049-81-0 simvastatin 
• 136006-71-8 4(R)-hydroxy-6(S)-<<2,4-dimethyl-6-methyl>phenoxy>methyl>tetrahydropyran-2-one 
• 136006-72-9 4(S)-hydroxy-6(S)-<<2,4-dimethyl-6-methyl>phenoxy>methyl>tetrahydropyran-2-one 
• 136034-00-9 Sodium; (3R,5S)-6-{2-[(S)-cyclohexyl-(2,2-dimethyl-butyryloxy)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate 
• 136034-01-0 Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyryloxy)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate 

Relevant academic research and scientific papers

ADAMANTYLMETHYLAMINE DERIVATIVE AND USE THEREOF AS PHARMACEUTICAL

The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt thereof.

Friedel-Crafts Reaction of 2-Methylfuran with Saturated and α,β-Unsaturated Acid Anhydrides

2-Methylfuran (5) reacts with the saturated acid anhydrides 16 - 26 in the presence of SnCl4 to give the 2-acyl-5-methylfurans 37 - 47 selectively.The unsaturated anhydrides 27 - 32, however, yield mixtures which only in the case of senecioic acid anhydride (29) contain the respective primary product 48.Subsequent reactions lead to the addition products 55 (from 27) and 56 (from 29), and to (E,Z)-mixtures of their enol esters 57 - 62 which could partially be separated and assigned. - The olfactory properties of 2, 37 - 48, 50, 52, and 53 were investigated.