81189-92-6Relevant articles and documents
Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species
Lin, Ruo-Kai,Lin, Yuh-Feng,Hsu, Ming-Jen,Hsieh, Chang-Lin,Wang, Chen-Yu,Huang, Chih-Chiang,Huang, Wei-Jan
supporting information, p. 5528 - 5533 (2016/11/09)
Some hydroxamate compounds induce cancer cell death by intracellular reactive oxygen species (ROS). This study introduced the hydroxamate core into lovastatin, a fungus metabolite clinically used for the treatment of hypercholesterolemia. The resulting co
Selective process for the deacylation of acylated compounds
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, (2008/06/13)
The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.