81189-92-6

Upstream product

• 108-24-7 acetic anhydride 
• 132748-10-8 (3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid 
• 145576-24-5 C₂₁H₃₀O₅ 
• 29138-64-5 α,α-dimethylbutanoic anhydride 
• 75330-75-5 lovastatin 

Downstream Products

• 210980-68-0 anhydrosimvastatin 
• 145576-25-6 simvastatin acetate 
• 851402-85-2 bis-simvastatin 
• 851402-84-1 4-simvastain-8-lovastatin 
• 123049-81-0 simvastatin 

Relevant academic research and scientific papers

Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

Some hydroxamate compounds induce cancer cell death by intracellular reactive oxygen species (ROS). This study introduced the hydroxamate core into lovastatin, a fungus metabolite clinically used for the treatment of hypercholesterolemia. The resulting co

METHODS FOR MAKING SIMVASTATIN AND INTERMEDIATES

The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.

Selective process for the deacylation of acylated compounds

The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.