29148-00-3 Usage
Chemical compound
4-Hexylbenzamidine hydrochloride
Salt form
Hydrochloride
Inhibitor
Potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5)
Enzyme
PRMT5, involved in histone methylation
Therapeutic potential
Studied for potential benefits in cancer treatment
Research use
Studies PRMT5 inhibition and its role in cellular processes and diseases
Tool
Important for understanding protein arginine methylation in biological systems
Check Digit Verification of cas no
The CAS Registry Mumber 29148-00-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,1,4 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 29148-00:
(7*2)+(6*9)+(5*1)+(4*4)+(3*8)+(2*0)+(1*0)=113
113 % 10 = 3
So 29148-00-3 is a valid CAS Registry Number.
29148-00-3Relevant articles and documents
Understanding binding affinity: A combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin
Talhout, Reinskje,Villa, Alessandra,Mark, Alan E.,Engberts, Jan B. F. N.
, p. 10570 - 10579 (2007/10/03)
The binding of a series of p-alkylbenzamidinium chloride inhibitors to the serine proteinase trypsin over a range of temperatures has been studied using isothermal titration (micro)calorimetry and molecular dynamics simulation techniques. The inhibitors h