291533-75-0Relevant academic research and scientific papers
Alkenyl- and alkynl-containing metalloprotease inhibitors
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, (2008/06/13)
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): where X, W, Z, A, G, R1, R2, R3, R4, R5, R5′and k have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof Also described are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines
Natchus,Bookland,Laufersweiler,Pikul,Almstead,De,Janusz,Hsieh,Gu,Pokross,Patel,Garver,Peng,Branch,King,Baker,Foltz,Mieling
, p. 1060 - 1071 (2007/10/03)
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typically
