291534-50-4Relevant academic research and scientific papers
Gold-Catalyzed Cycloisomerization of Alkyne-Containing Amino Acids: Controlled Tuning of C–N vs. C–O Reactivity
Medran, Noelia S.,Villalba, Matías,Mata, Ernesto G.,Testero, Sebastián A.
supporting information, p. 3757 - 3764 (2016/08/16)
Versatile alkyne-containing amino acids were used as ambident precursors in the divergent synthesis of alkylidenelactones and 1-pyrrolines. Two gold-catalyzed protocols were applied for selective intramolecular O- and N-cycloisomerization reactions.
Transition metal-catalyzed synthesis of novel biologically relevant tryptophan analogues
Van Esseveldt, Bart C. J.,Van Delft, Floris L.,Smits, Jan M. M.,De Gelder, Rene,Schoemaker, Hans E.,Rutjes, Floris P. J. T.
, p. 823 - 834 (2007/10/03)
A synthetic approach to the synthesis of novel tryptophan derivatives and benzofuran-containing amino acids is detailed. The sequence starts from enzymatically resolved enantiopure acetylene-containing amino acids, of which the acetylene function can be e
Palladium-catalyzed synthesis of novel optically active tryptophan analogues
Van Esseveldt, Bart C. J.,Van Delft, Floris L.,De Gelder, Rene,Rutjes, Floris P. J. T.
, p. 1717 - 1720 (2007/10/03)
(Matrix presented) Both unsaturated proline derivatives and optically active tryptophan analogues have been obtained via Pd-catalyzed cyclization of aniline-containing acetylenic amino acids. The side chain length of the cyclization precursor determines w
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines
Natchus,Bookland,Laufersweiler,Pikul,Almstead,De,Janusz,Hsieh,Gu,Pokross,Patel,Garver,Peng,Branch,King,Baker,Foltz,Mieling
, p. 1060 - 1071 (2007/10/03)
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typically
