291544-75-7Relevant academic research and scientific papers
Preparation and Atropisomerism of 1-(2-Aryl)-piperidin-2-ones
Moehrle,Jeandree,Breitmaier,Rohonczy
, p. 473 - 485 (2007/10/03)
Course and rate of the dehydrogenation of N-tertiary piperidines dependent on their substitution in 4-position and on the hydroxy bearing neighbor group were examined, using mercury(II)-EDTA and the model amino alcohols 1a-1e, 3a-3f, 8a-8f and 10a-10f. The results showed that increasing size of 4-substituents and neighbor groups too decreased the rate of reaction. The products from the 2-substituted benzylic alcohols, the 2-piperidones 7a-7g, 9a-9g and 11a-11g demonstrated atropisomerism. In the case of chiral neighbor groups diastereomeric mixtures were formed.
