29171-72-0

Usage

Uses

Used in Pharmaceutical Industry:
4-[(DIPROPYLAMINO)SULFONYL]BENZENE-1-CARBONYL CHLORIDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to introduce the carbonyl chloride group into other molecules, facilitating the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 4-[(DIPROPYLAMINO)SULFONYL]BENZENE-1-CARBONYL CHLORIDE serves as an intermediate in the production of agrochemicals, contributing to the synthesis of compounds that enhance crop protection and yield.
Used in Organic Chemistry Research:
4-[(DIPROPYLAMINO)SULFONYL]BENZENE-1-CARBONYL CHLORIDE is utilized as a reagent in organic chemistry reactions, enabling the introduction of the carbonyl chloride group into target molecules for the exploration of new chemical reactions and the synthesis of novel organic compounds.

InChI:InChI=1/C13H18ClNO3S/c1-3-9-15(10-4-2)19(17,18)12-7-5-11(6-8-12)13(14)16/h5-8H,3-4,9-10H2,1-2H3

Upstream product

• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 57-66-9 4-[(dipropylamino)sulfonyl]benzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 142-84-7 di-n-propylamine 

Downstream Products

• 10252-86-5 4-cyano-N,N-dipropylbenzenesulfonamide 
• 1658-96-4 4-acetyl-N,N-dipropylbenzenesulfonamide 
• 58655-50-8 chloromethyl 4-(N,N-di-propylsulfamoyl)benzoate 

Relevant academic research and scientific papers

Discovery of novel bacterial RNA polymerase inhibitors: Pharmacophore-based virtual screening and hit optimization

The bacterial RNA polymerase (RNAP) is a validated target for broad spectrum antibiotics. However, the efficiency of drugs is reduced by resistance. To discover novel RNAP inhibitors, a pharmacophore based on the alignment of described inhibitors was used for virtual screening. In an optimization process of hit compounds, novel derivatives with improved in vitro potency were discovered. Investigations concerning the molecular mechanism of RNAP inhibition reveal that they prevent the protein-protein interaction (PPI) between σ70 and the RNAP core enzyme. Besides of reducing RNA formation, the inhibitors were shown to interfere with bacterial lipid biosynthesis. The compounds were active against Gram-positive pathogens and revealed significantly lower resistance frequencies compared to clinically used rifampicin.

Discovery and initial development of a novel class of antibacterials: Inhibitors of Staphylococcus aureus transcription/translation

The novel bacterial transcription/translation (TT) inhibitor 1 was identified through a combination of high throughput screening and exploratory medicinal chemistry. Initial optimization of the anthranilic acid moiety and sulfonamide amine diversity was accomplished via 1- and two-dimensional solution phase libraries, resulting in an improvement in the MIC of the lead from 64 to 8 μg/mL (compound 4l). Subsequent modification of the central aromatic ring and further refinement of the sulfonamide amines required the development of a solid phase route on Wang resin. The resulting libraries generated a number of potent antibacterials with MICs of ≤1 μg/mL (e.g., 10b, 12, and 13). During the course of this work, it became apparent that the antibacterial activity of the series is not fully correlated with TT inhibition, suggesting that at least one additional mechanism of action is operative.

Probenecidoxymethyl and 1-ethyl esters of ampicillin

New ampicillin derivatives, probenecidoxymethyl and 1-ethyl esters of ampicillin and their pharmaceutically acceptable salts, useful as antibiotics. A method for preparing these antibiotics by condensing probenecidoxymethyl or 1-ethyl halide with an acid