58655-50-8Relevant articles and documents
Amoxicillin derivative as well as preparation method and application thereof
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Paragraph 0020; 0049-0050; 0054, (2020/08/02)
The invention provides an amoxicillin derivative with a structure shown as a formula I or a pharmaceutically and/or veterinary acceptable solvate of the amoxicillin derivative, wherein R is a hydrogenatom, an alkyl group, an amino group, a hydroxyl group, an amidino group, a guanidino group, a nitro group, a sulfonyl group or a group containing one of the alkyl group, the amino group, the hydroxyl group, the amidino group, the guanidino group, the nitro group and the sulfonyl group. According to the invention, two different lead compounds are connected together through a covalent bond to generate a synergistic effect, an addition effect or new pharmacological activity in vivo; benzoic acid is spliced to an amoxicillin side chain to generate a new amoxicillin-benzoic acid derivative, and the obtained new compound can broaden the antibacterial spectrum, has good antibacterial activity on gram-positive bacteria and gram-negative bacteria, and is effective for drug-resistant bacteria.