29177-84-2 Usage
Uses
Used in Pharmaceutical Industry:
ETHYL LOFLAZEPATE is used as an anti-anxiety agent for its potent anticonflict effects, providing relief from anxiety and stress. It is particularly effective when compared to other benzodiazepines such as Diazepam and Lorazepam.
Used in Research and Development:
ETHYL LOFLAZEPATE serves as a valuable compound in the development of new anti-anxiety medications. Its comparison with other benzodiazepines like Diazepam, Nitrazepam, and Lorazepam helps researchers understand its potential benefits and drawbacks, leading to the creation of more effective and safer drugs for anxiety treatment.
Originator
Victan,Clin Midy,France,1982
Manufacturing Process
(A) 1-(2-Amino-5-chlorophenyl)-1-(2-fluorophenyl)-2-aza-buty1-en-4-ol: A
mixture of 40 g of 2-methylimidazole hydrochloride and of 90 g of 2-amino-5-
chloro-2'-fluoro-benzophenone in 240 ml of ethanolamine is heated at 135°C
for 2 hours. After cooling, the reaction mixture is poured into an aqueous
sodium bicarbonate solution. The mixture is extracted with ether, the organic
phase is washed repeatedly with water and is dried over sodium sulfate, and
the solvent is evaporated to dryness. The residual oil is chromatographed on a
silica column, elution being carried out with a 50/50 mixture of cyclohexane
and ethyl acetate.88 g of the expected amine are thus isolated. Melting point: 105°C to 110°C.(B)1-(2-Amino-5-chlorophenyl)-1-(2-fluorophenyl)-3,3-bis-(ethoxycarbonyl)-2-
aza-prop-1-ene: A mixture of 88 g of the product obtained above, 300 g of
ethyl aminomalonate hydrochloride and 60 ml of acetic acid in 2.3 liters of
absolute ethanol is heated to the reflux temperature for 6 hours. The alcohol
and the acetic acid are evaporated in vacuo and the residue is taken up in
ether. The solution is washed with a dilute sodium bicarbonate solution and
then with water and is dried over sodium sulfate. The solvent is evaporated
and the residue is then chromatographed on a silica column, using a 90/10
mixture of chloroform and ethyl acetate for the elution. An oil (64g) is thus
obtained, and is used, without further treatment, for the cyclization.A sample recrystallized from isopropyl ether has a melting point of 119°C.(C) Compound of Code No. CM 6912: 25 g of the imine obtained under (B),
dissolved in 400 ml of acetic acid, are heated at the reflux temperature for 1
hour. After evaporating the solvent in vacuo, the residue is taken up in
methylene chloride. The solution is washed with a dilute sodium bicarbonate
solution and then with water. After evaporating the solvent, the residue is
chromatographed on silica, elution being carried out with an 80/20 mixture of
ether and ethyl acetate. 9 g of benzodiazepine are thus obtained. Melting
point: 196°C.
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 29177-84-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,1,7 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 29177-84:
(7*2)+(6*9)+(5*1)+(4*7)+(3*7)+(2*8)+(1*4)=142
142 % 10 = 2
So 29177-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)
This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn't provide relevant sales information.